Continuous Wave Imaging

 

Haidong LIANG

Head of New Technologies, Dept. of Medical Physics and Bioengineering,

University Hospitals Bristol NHS Foundation Trust

 

 

Time & Date: 15:30, June.14, 2012
Place:    Room 521, Physics Building
Speaker:  Haidong LIANG

 

Abstract:

This talk is based on transmission of continuous ultrasound illuminating a rotating object (or stationary target with orbiting probe), and Fourier analysis of rotationally symmetric echo is presented. High spatial-resolution can be achieved by coherent image processing method to reconstruct the image. The full width half maximum spatial resolution is around 0.25 wavelengths. To show the performance of the method, we present the results obtained by applying the new technique in simulation and experiment. Phantoms consist of very thin copper wires, and those constructed by tissue-mimicking-material were scanned. It is demonstrated that the copper wires were located very accurately with very high spatial resolution, and good shape approximation for the cylindrical phantoms was achieved.

 

 

CV

 

Name:  Haidong LIANG

 

Education and Qualification:

10/95—02/99  PhD   Biomedical Engineering, University of Surrey

09/86—06/92  BEng    Biomedical Engineering , Shanghai Medical University

 

Work Experience:

7/2003 - to date Head of New Technologies, Dept of Medical Physics and Bioengineering, University Hospitals Bristol NHS Foundation Trust

Research and Development of medical ultrasound, including ultrasonic microscanning, molecular imaging, ultrasound-medicated gene therapy; supervising MSc students; providing computing, technical and engineering expertise for the Directorate of Medical Physics and Bioengineering.

11/2001-7/2003 Research Associate and Biological Ultrasound Facility Manager, Imaging Sciences Department, Imperial College London

Developing novel ultrasound-mediated gene therapy method to optimise the DNA uptake by cells; ultrasonic signal processing of synthetic aperture focusing technique, 3D incoherent continuous wave ultrasonic Doppler tomography; supervising undergraduate students.

2/1999-11/2001 Research Associate, Centre for Physical and Engineering Research in Medicine, University of Bristol

Developing multiple dimensional scanning acoustic microscopy with reflection, reflex transmission, synthetic aperture and continuous wave Doppler modes to be used in biomedical imaging.

10/1995- 2/1999 PhD study, Biomedical Engineering Group, School of Mechanical and Materials Engineering, University of Surrey

Developing the methodology of using the high frequency ultrasound technology to measure the facial soft tissue thickness and registering the thickness data into laser scanned 3D designing model able to be used in finite element analysis for simulating the soft tissue deformation under high g loading and the oxygen mask/tissue interaction; Teaching assistant in physiological measurement course for MSc students and helping supervising undergraduate and MSc student projects.

7/1992-10/1995 Design engineer, The Second Academy of China Aerospace Ministry

Developing the Gamma camera image acquisition and processing system and R-wave detector.

9/1991-2/1992 Student trainee, Zhongshan and Huashan hospitals in Shanghai

Placement in Departments such as Ultrasound, Radiology, MRI and CT.

9/1990-8/1991 Research assistant, Dept of Biomedical Engineering, Shanghai Medical University

Developing the laryngeal stroboscope, heart-rate and breath-rate meter.

 

Membership of Professional Bodies

01/2009- to date Member of British Medical Ultrasound Society

11/2003- to date Corporate member of the Institute of Physics and Engineering in Medicine (IPEM). 

11/2005- to date State Registered Clinical Scientist (Registration number: CS09707) 

 

 

Research grants (All principal investigators)

10/2009-09/2010 Research Grant (£99,908) from National Institute for Health Research, Very high resolution continuous wave ultrasonic Doppler tomography for biomedical imaging.

06/2010-05/2011 Research Grant (£99,857) from National Institute for Health Research, Ultrasonic thermography for determining potential hazards in diagnostic ultrasound

06/2010-05/2011 Research Grant (£99,685) from National Institute for Health Research, Enhanced through-transmission ultrasonic tomography for breast imaging using novel phase-insensitive pyroelectric detectors

 

Honours and Professional Activities:

1.    04/2011-to date   Member of British Medical Ultrasound Society Safety Committee

2.    11/2010- to date Membership of Above and Beyond Charity Research Funding Committee

3.    07/2010-to date   Honorary Senior Research Fellow in Cardiff Universtiy

4.    07/2007-06/2010 Honorary Senior Lecturer in Cardiff University.

5.    09/2008-08/2011 Member of Ultrasound and NonIonizing Radiation Special Interest Group of IPEM.

6.    5/2002- to date On the Advisory Editorial Board of Journal Ultrasound in Medicine and Biology, the Official Journal of the World Federation for Ultrasound in Medicine and Biology.

7.    Journal referee for Biomedical Engineering online, Cell Biology International, Cell Biochemistry and biophysics, Gene Therapy, Journal of Controlled Release, Journal of Engineering in Medicine, Journal of Experimental Pharmacology, Medical and Biological Engineering and Computing, Ultrasonics and Ultrasound in Medicine and Biology.

8.    1995-1998 University of Surrey Studentship and Overseas Research Studentship from the UK government

9.    1993-1995 Outstanding Young Scientific Worker in the Second Academy of China Aerospace Ministry

10.  1991 Excellent Student's Scientific Thesis in Shanghai Medical University

11.  1987 National University Student Physics Competition Prize

Invited speaker and meeting organiser:

1.    05/2012 Invited speaker in 9th International Symposium on Modern Acoustics in Nanjing

2.    03/2011 Scientific organiser of Biennial IPEM Physics and Technology of Medical Ultrasound meeting

3.    09/2010 Invited speaker in British Medical Ultrasound Society Annual Scientific Meeting in Brighton.

4.    12/2006 Invited speaker in British Medical Ultrasound Society Annual Scientific Meeting in Manchester.

5.    9/2002 Invited speaker in “Biomedical Futures Conference”, organised by the Royal Academy of Engineering.

6.    10/2000 Invited speaker in “8th International Workshop on Modern Acoustics (NDE)” in Nanjing, China.

 

 

 

Publications

Refereed journal papers:

Wells P.N.T., Liang H.D. (2011)  “Medical ultrasound: imaging of soft tissue strain and elasticity”. Journal of Royal        Society Interface 8: 1521-1549

Liang H.D. Tsui C.S.L., Halliwell M., Wells P.N.T. (2011) “Continuous wave ultrasonic Doppler tomography”. Interface Focus 1: 665-672

Zhou L.X., Beach K.W., Liang H.D., Halliwell M., Wells P.N.T. (2011). “Noninvasive measurement of local arterial        pulse wave velocity in humans by ultrasound”. Journal of Medical Engineering & Technology 35 (6-7): 362-369

Wells P.N.T., Liang H.D., Young T.P.  (2011). “Ultrasonic imaging technologies in perspective”. Journal of Medical        Engineering & Technology 35 (6-7): 289-299

Tsui C.S.L., Liang H. D., Halliwell M., Shere M, Braybrooke J.P., Whipp E., Wells P.N.T. (2011). “Coherent ultrasonic Doppler tomography”. Ultrasound in Medicine and Biology 37(4):642-50.

Liang H. D., Tang J., Halliwell M. (2010). “Sonoporation, drug delivery and gene therapy”. Journal of Engineering in Medicine. 224(2):343-361.

Xenariou S., Liang H. D. et al (2010) “Low-frequency ultrasound increases non-viral gene transfer to the mouse lung”. Acta Biochimica et Biophysica Sinica. 42(1):45-51

Liang H. D., Zhou L. X., Wells P.N.T., Halliwell M. (2009). “Temperature measurement by thermal strain imaging with diagnostic power ultrasound, with potential for thermal index determination”. Ultrasound in Medicine and Biology 35(5):773-78

Zhao, Y. Z., Luo, Y. K., Lu, C. T., Xu, J. F.,Tang, J.,Zhang, M.,Zhang, Y., Liang, H. D. (2008). “Phospholipids-based microbubbles sonoporation pore size and reseal of cell membrane cultured in vitro”. Journal of Drug Targeting 16(1): 18-25

Xenariou S., Griesenbach U., Liang H.D., et al. (2007). “Use of ultrasound to enhance nonviral lung gene transfer in vivo”. Gene Therapy 14(9): 768-774.

Chen Y. C., Liang H. D., et al. (2006). "Pluronic block copolymers: Novel functions in ultrasound-mediated gene transfer and against cell damage." Ultrasound in Medicine and Biology 32(1): 131-137.

Zhao Y. Z., LuoY. K., Liang H. D. et al. (2006). "Comparing transfection efficiency and safety for antisense oligodeoxyribonucleotide between phospholipids-based microbubbles and liposomes." Journal of Drug Targeting 14(10): 687-693

Zhao, Y. Z., Liang H. D., et al. (2005). "Preparation, characterization and in vivo observation of phospholipid-based gas-filled microbubbles containing hirudin." Ultrasound in Medicine and Biology 31(9): 1237-1243.

Wang, X. H., Liang H. D., et al. (2005). "Gene transfer with microbubble ultrasound and plasmid DNA into skeletal muscle of mice: Comparison between commercially available microbubble contrast agents." Radiology 237(1): 224-229.

Liang H. D., Lu Q. L, Xue S. A., Halliwell M., Kodama T., Cosgrove D. O., Stauss H. J., Partridges T. A. and Blomley M. J. K. (2004) Optimisation of ultrasound-mediated gene transfer (sonoporation) in skeletal muscle cells. Ultrasound Medicine and Biology 30:1523-1529.

Liang H. D., Wang X. H., Sennoga C., Halliwell M., Cosgrove D. O., Blomley M. J. K.(2004) Ultrasound Contrast Agents Imaging and Therapeutic Applications. Chinese Journal of Medical Ultrasound (electrionica version) 1:138-141.

Liang, H. D. and Blomley, M. J. K. (2003) The role of ultrasound in molecular imaging. British Journal of Radiology, 76:S2140-150.

Liang, H. D., Halliwell, M., and Wells, P. N. T. (2003). Incoherent imaging using continuous wave ultrasound. A preliminary study using of bovine intervertebral disc. European Journal of Ultrasound 16, 253-260.

Lu, Q. L., Liang, H. D., Partridge, T., and Blomley, M. J. K. (2003). Microbubble ultrasound improves the efficiency of gene transduction in skeletal muscle in vivo with reduced tissue damage. Gene Therapy 10, 396-405.

Liang, H. D., Halliwell, M., and Wells, P. N. T. (2001). Continuous wave ultrasonic tomography. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 48, 285-292.

Liang, H. D., Halliwell, M., and Wells, P. N. T. (2001). Continuous wave ultrasonic tomography in NDE. Progress in Natural Science 11, S151-S155.

Liang, H. D., and Zhou, L. X. (1995). R-wave detector for Gamma camera. Journal of Chinese Medical Instrumentation 19, 23-26.

Wang, J. B., Liang, H. D., and Jiang, Y. M. (1992). The development of rhino-larynx stroboscope based on microcomputer. Journal of Chinese Medical Instrumentation 16, 89-91.

 

Unrefereed conference papers

 

Liang, H. D.,Halliwell, M. (2007). Ultrasonic elasticity imaging, SYNERGY Imaging & Therapy Practice July 2007

Liang, H. D.,Halliwell, M. (2007) Microbubble drug delivery, RAD Magazine, September 2007.

Liang, H. D.,Halliwell, M., Eckersley, R. J., and Wells, P. N. T. (2002). Continuous wave ultrasonic tomography and future of medical ultrasound. In "BioMedical Futures Conference" (R. Kitney, ed.),  Birmingham.

Liang, H. D., Halliwell, M., and Wells, P. N. T. (2001). An effect of scatterer size on reflex transmission imaging. In "26th International Acoustical Imaging Symposium" (R. Maev, ed.), Vol. 26, pp. 461-466. Kluwer Academic/Plenum Publishers, Windsor, Ontario, Canada

Liang, H. D., Halliwell, M., and Wells, P. N. T. (2000). Doppler ultrasonic imaging. In "25th International Acoustical Imaging Symposium" (P. N. T. Wells and M. Halliwell, eds.), Vol. 25, pp. 279-288. Kluwer Academic/Plenum Publishers, Bristol, UK.

Liang, H. D., Daya A., and Hughes S. C. (1998). In vivo facial soft tissue thickness measurement.  SPIE Proc Vol. 3254.San. Jose, USA.

Liang, H. D., and Hughes S. C. (1998) 3D maxillofacial soft tissue model in laser scanned head. SPIE Proc Vol. 3254.San. Jose, USA.

Liang H. D., and Hughes S. C. (1997) Soft tissue properties in a design system for aircrew headworn equipment. The Proc of "The design and integration of helmet systems". Framingham, USA.